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Writer's pictureJulie Smullen

Relationship between obesity and female subfertility & infertility.

Female Infertility, defined as the inability to conceive after 12 months of unprotected sex, is becoming a major global health concern alongside the rising obesity issue. Overweight and obese women need longer time to conceive and undoubtedly are at higher risk of infertility. (4)


The rising global prevalence of obesity and its profound impact on female reproductive health has become a pressing concern. Obesity’s systemic effects, from hormonal imbalances to inflammation, disrupt the intricate processes of female fertility. (1)


Studies show that overweight and obese women often experience subfertility. For example, an observational study of 2,112 pregnant women found that a BMI over 25 was linked to longer times to conceive. (3)


Once pregnant, obese women are at higher risk for adverse pregnancy outcomes. Weight loss improves reproductive potential in obese patients. Evidence does however show obese women that surpass 35 years of age, age may be more important than body mass index in determining reproductive potential. (2)


Recently, there has been growing interest in how lifestyle factors, like stress, habits, and overall well-being, affect health. Several factors negatively impact fertility, including psychological stress from social life and work, smoking, drug use, caffeine, alcohol, diet, and body weight changes. (4) Addressing these lifestyle factors is essential for improving reproductive health.

Beyond the immediate health implications for the affected individuals, there are broader societal and economic repercussions. (1) It can cause deep emotional distress, harm relationships, and lower quality of life. In many cultures, where childbearing is highly valued, infertility can lead to stigma and social isolation. (1)


There is assisted reproductive technologies (ART), such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), which have emerged as revolutionary tools in the realm of reproductive medicine, offering hope to countless couples facing infertility challenges. (1) However, while assisted reproductive technologies (ART) offer hope, their effectiveness can be impacted by weight.


A high percentage of obese women, pregnancy occurs with normal accomplishment, several risks in their conception plans need to be considered and discussed. (4) Their risks need careful consideration. Comprehensive preconception care, including education on healthy lifestyle changes, is crucial. Weight loss programs through lifestyle modification in obese women, have been proven to restore menstrual cyclicity and ovulation and improve the likelihood of conception. (4) Additionally, psychological support can play a vital role in helping women navigate the emotional challenges associated with infertility and obesity.


Overall, addressing both the physical and emotional aspects of infertility in obese women is key to improving reproductive health outcomes. By prioritizing education and support, we can enhance reproductive health and help individuals achieve their family planning goals fostering a supportive environment for those trying to conceive. If you think obesity is affecting your ability to conceive, it’s important to have a discussion incorporating the Key points discussed in this article with your Health or Nutrition Consultant.



References

1.       Zheng L, Yang L, Guo Z, Yao N, Zhang S, Pu P. Obesity and its impact on female reproductive health: unravelling the connections. Front Endocrinol (Lausanne). 2024 Jan 9;14:1326546. doi: 10.3389/fendo.2023.1326546. PMID: 38264286; PMCID: PMC10803652. Obesity and its impact on female reproductive health: unraveling the connections - PMC (nih.gov)

2.       Klenov VE, Jungheim ES. Obesity and reproductive function: a review of the evidence. Curr Opin Obstet Gynecol. 2014 Dec;26(6):455-60. doi: 10.1097/GCO.0000000000000113. PMID: 25254319. Obesity and reproductive function: a review of the evidence - PubMed (nih.gov)

3.       Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Biomed. 2022 Aug 31;93(4):e2022278. doi: 10.23750/abm.v93i4.13466. PMID: 36043953; PMCID: PMC9534231. Female obesity and infertility: outcomes and regulatory guidance - PMC (nih.gov)

4.       Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018 Mar 9;16(1):22. doi: 10.1186/s12958-018-0336-z. PMID: 29523133; PMCID: PMC5845358. Obesity as disruptor of the female fertility - PMC (nih.gov)

 


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